Ephrin A5 Information: Ephrin A5 Protein, Ephrin A5 Antibody and Ephrin A5 Gene

Ephrin A5 Gene family

Ephrin A5 Protein

Ephrin A5 protein function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. {ECO:0000269|PubMed:10601038, ECO:0000269|PubMed:11870224}.

Ephrin A5 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    228.00
  • Mass (KDa)
    26.00

Ephrin A5 Antibody

There are 1 Ephrin A5 antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 Ephrin A5 antibody for IHC-P. Among all these Ephrin A5 antibodies, there are 1 anti-Ephrin A5 rabbit polyclonal antibodies . All the Ephrin A5 anbodies are produced in house and all are in stock. Ephrin A5 antibody customerized service is available.

Ephrin A5 Gene

EFNA5 gene / cDNA is a protein-coding gene which located on 5q21.3. The EFNA5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.217 organisms have orthologs with human gene EFNA5.