ERK2 Gene Sequence, Family, Fuction and Expression Information
ERK2 cDNA / Gene Overview
MAPK1 gene / cDNA is a protein-coding gene which located on 22q11.22. The MAPK1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, A.thaliana, rice, and frog.215 organisms have orthologs with human gene MAPK1.
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
ERK2 cDNA / Gene Sequence
LOCUS NM_002745 5916 bp mRNA linear PRI 05-AUG-2018
Homo sapiens mitogen-activated protein kinase 1 (MAPK1), transcript variant 1, mRNA.
This sequence information is just for reference only.
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