Fas/CD95 Information: Fas/CD95 Protein, Fas/CD95 Antibody and Fas/CD95 Gene

Fas/CD95 Gene family

Fas/CD95 Protein

Fas/CD95 protein function

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181}.

Fas/CD95 protein expression

Tissue specificity

Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.

Fas/CD95 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

Fas/CD95 Antibody

There are 25 Fas/CD95 antibodies which are validated in multiple tissues with various applications, including ELISA, FCM, ELISA(Cap), ELISA(Det), ICC/IF. There are 13 Fas/CD95 antibody for ELISA, 10 Fas/CD95 antibody for FCM, 1 Fas/CD95 antibody for ELISA(Cap), 1 Fas/CD95 antibody for ELISA(Det), 1 Fas/CD95 antibody for ICC/IF. Among all these Fas/CD95 antibodies, there are 8 anti-Fas/CD95 mouse monoclonal antibodies , 10 anti-Fas/CD95 rabbit monoclonal antibodies , 7 anti-Fas/CD95 rabbit polyclonal antibodies . All the Fas/CD95 anbodies are produced in house and all are in stock. Fas/CD95 antibody customerized service is available.

Fas/CD95 Gene

FAS gene / cDNA is a protein-coding gene which located on 10q23.31. The FAS gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.177 organisms have orthologs with human gene FAS.