FLT1 Gene Sequence, Family, Fuction and Expression Information
FLT1 cDNA / Gene Overview
FLT1 gene / cDNA is a protein-coding gene which located on 13q12.3. The FLT1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and zebrafish.213 organisms have orthologs with human gene FLT1.
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
FLT1 cDNA / Gene Sequence
LOCUS NM_002019 7123 bp mRNA linear PRI 01-JUL-2018
Homo sapiens fms related tyrosine kinase 1 (FLT1), transcript variant 1, mRNA.
This sequence information is just for reference only.
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