Fractalkine Information: Fractalkine Protein, Fractalkine Antibody and Fractalkine Gene

Fractalkine Gene family

Fractalkine Protein

Fractalkine protein function

Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350). {ECO:0000269|PubMed:21829356, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:9024663, ECO:0000269|PubMed:9177350, ECO:0000269|PubMed:9931005}.

Fractalkine protein expression

Tissue specificity

Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart.

Induction

By TNF and IL1/interleukin-1 in pulmonary endothelial cells and umbilical vein endothelial cells.

Fractalkine protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    397.00
  • Mass (KDa)
    42.00

Fractalkine Antibody

There are 8 Fractalkine antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Cap), ELISA(Det), IHC-P. There are 6 Fractalkine antibody for ELISA, 1 Fractalkine antibody for ELISA(Cap), 1 Fractalkine antibody for ELISA(Det), 3 Fractalkine antibody for IHC-P. Among all these Fractalkine antibodies, there are 1 anti-Fractalkine mouse monoclonal antibodies , 3 anti-Fractalkine rabbit monoclonal antibodies , 4 anti-Fractalkine rabbit polyclonal antibodies . All the Fractalkine anbodies are produced in house and all are in stock. Fractalkine antibody customerized service is available.

Fractalkine Gene

CX3CL1 gene / cDNA is a protein-coding gene which located on 16q21. The CX3CL1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.144 organisms have orthologs with human gene CX3CL1.