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GM-CSF Receptor alpha: GM-CSF Receptor alpha Protein | GM-CSF Receptor alpha Antibody

GM-CSF Receptor alpha Gene family

GM-CSF Receptor alpha Background

CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes.

Reference for GM-CSF Receptor alpha

  • Sjöblom C, et al. (2002) Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos. Biol Reprod. 67(6): 1817-23.
  • Goldstein JI, et al. (2011) Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 141(1): 208-16.
  • Saulle E, et al. (2009) Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation. Br J Haematol. 145(3): 399-411.

GM-CSF Receptor alpha Protein

GM-CSF Receptor alpha protein function

Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

GM-CSF Receptor alpha protein sequence

This sequence information is just for reference only.From Uniport

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  • Mass (Da)

GM-CSF Receptor alpha Antibody

There are 10 GM-CSF Receptor alpha antibodies which are validated in multiple tissues with various applications, including ELISA, FCM. There are 5 GM-CSF Receptor alpha antibody for ELISA, 6 GM-CSF Receptor alpha antibody for FCM. Among all these GM-CSF Receptor alpha antibodies, there are 3 anti-GM-CSF Receptor alpha mouse monoclonal antibodies , 5 anti-GM-CSF Receptor alpha rabbit monoclonal antibodies , 2 anti-GM-CSF Receptor alpha rabbit polyclonal antibodies . All the GM-CSF Receptor alpha anbodies are produced in house and all are in stock. GM-CSF Receptor alpha antibody customerized service is available.

GM-CSF Receptor alpha Gene

CSF2RA gene / cDNA is a protein-coding gene which located on Xp22.32 and Yp11.3. The CSF2RA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.67 organisms have orthologs with human gene CSF2RA.