Her2/ERBB2 Information: Her2/ERBB2 Protein, Her2/ERBB2 Antibody and Her2/ERBB2 Gene

Her2/ERBB2 Gene family

Her2/ERBB2 Protein

Her2/ERBB2 protein function

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}.

Her2/ERBB2 protein expression

Tissue specificity

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Her2/ERBB2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,255.00
  • Mass (KDa)
    137.00

Her2/ERBB2 Antibody

There are 43 Her2/ERBB2 antibodies which are validated in multiple tissues with various applications, including ELISA, FCM, ICC/IF, IHC-P, ELISA(Det), ELISA(Cap), WB, IP. There are 24 Her2/ERBB2 antibody for ELISA, 15 Her2/ERBB2 antibody for FCM, 6 Her2/ERBB2 antibody for ICC/IF, 8 Her2/ERBB2 antibody for IHC-P, 1 Her2/ERBB2 antibody for ELISA(Det), 1 Her2/ERBB2 antibody for ELISA(Cap), 9 Her2/ERBB2 antibody for WB, 2 Her2/ERBB2 antibody for IP. Among all these Her2/ERBB2 antibodies, there are 12 anti-Her2/ERBB2 mouse monoclonal antibodies , 13 anti-Her2/ERBB2 rabbit monoclonal antibodies , 18 anti-Her2/ERBB2 rabbit polyclonal antibodies . All the Her2/ERBB2 anbodies are produced in house and all are in stock. Her2/ERBB2 antibody customerized service is available.

Her2/ERBB2 Gene

ERBB2 gene / cDNA is a protein-coding gene which located on 17q12. The ERBB2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.199 organisms have orthologs with human gene ERBB2.