ICAM4 Gene Sequence, Family, Fuction and Expression Information
ICAM4 cDNA / Gene Overview
ICAM4 gene / cDNA is a protein-coding gene which located on 19p13.2. The ICAM4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.119 organisms have orthologs with human gene ICAM4.
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
ICAM4 cDNA / Gene Sequence
LOCUS NM_001544 1354 bp mRNA linear PRI 25-JUN-2018
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