ICAM4 Gene Sequence, Family, Fuction and Expression Information

ICAM4 cDNA / Gene Overview

ICAM4 gene / cDNA is a protein-coding gene which located on 19p13.2. The ICAM4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.119 organisms have orthologs with human gene ICAM4.

ICAM4 cDNA / Gene Function

This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

ICAM4 cDNA / Gene Sequence

LOCUS
LOCUS NM_001544 1354 bp mRNA linear PRI 25-JUN-2018
DEFINITION
Homo sapiens intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) (ICAM4), transcript variant 1, mRNA.
ACCESSION
NM_001544
VERSION
NM_001544.4

This sequence information is just for reference only.

ICAM4 Family & Reagents

ICAM4 Gene family reagents (Blood group antigens)

Approved Symbol Reagent list
ABO
ART4
BSG
CD55
CD99
GYPC
Approved Symbol Reagent list
ACHE
BCAM
CD44
CD59
GYPA
XG

ICAM4 Gene family reagents (CD molecules)

Approved Symbol Reagent list
IGF1R
IL18R1
ERBB2
TFRC
TLR2
NT5E
SLAMF8
TNFRSF14
MS4A1
CD226
Approved Symbol Reagent list
EpCAM
IL3Ra
BTN3A1
CLEC10A
CD7
IL1R2
FCAR
CD96
CD2
TNFRSF8

ICAM4 Gene family reagents (Immunoglobulin like domain containing)

Approved Symbol Reagent list
VTCN1
NTRK1
LY9
CNTN2
FCRL2
CXADR
FLT3
KIRREL3
TEK
FCGR2B
Approved Symbol Reagent list
CD47
IL1RAPL1
CEACAM8
PECAM1
CEACAM5
SEMA4D
ESAM
IL1RAPL2
NECTIN2
A1BG

ICAM4 Gene family reagents (Ig-like cell adhesion molecule family)

Approved Symbol Reagent list
CNTN2
JAM2
FGFRL1
SLAMF1
NECTIN4
F11R
CRTAM
PECAM1
CADM4
ROBO2
Approved Symbol Reagent list
ICAM1
SIRPA
LRRC4C
MCAM
ALCAM
IZUMO1
CD58
CD2
CHL1
VCAM1

ICAM4 cDNA / Gene Alias

  • CD242

ICAM4 cDNA / Gene Expression

Biased expression in lung (RPKM 3.3), bone marrow (RPKM 3.1) and 13 other tissues