IGFBP7 Gene Sequence, Family, Fuction and Expression Information

IGFBP7 cDNA / Gene Overview

IGFBP7 gene / cDNA is a protein-coding gene which located on 4q12. The IGFBP7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.211 organisms have orthologs with human gene IGFBP7.

IGFBP7 cDNA / Gene Function

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

IGFBP7 cDNA / Gene Sequence

LOCUS
LOCUS NM_001253835 1051 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens insulin like growth factor binding protein 7 (IGFBP7), transcript variant 2, mRNA.
ACCESSION
NM_001253835
VERSION
NM_001253835.1

This sequence information is just for reference only.

IGFBP7 Family & Reagents

IGFBP7 Gene family reagents (I-set domain containing)

Approved Symbol Reagent list
CNTN5
IGSF11
KIRREL1
NRG2
LRRC4C
KIRREL2
ROR1
FSTL5
PDGFRB
VCAM1
Approved Symbol Reagent list
MUSK
MERTK
FGFR3
FGFR1
CNTN4
OPCML
KIRREL3
ADAMTSL1
IL1R1
PTK7

IGFBP7 cDNA / Gene Alias

  • FSTL2
  • IGFBP-7
  • MAC25
  • PSF

IGFBP7 cDNA / Gene Expression

Broad expression in kidney (RPKM 607.4), gall bladder (RPKM 382.6) and 21 other tissues