IL-1 R9: IL-1 R9 Protein | IL-1 R9 Antibody

IL-1 R9 Gene family

IL-1 R9 Background

X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) or Interleukin-1 receptor 9 (IL-1R9) is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins. IL-1R9/IL1RAPL2 shows restricted expression in fetal brain and is highly homologous to IL1RAPL, which is reportedly involved in nonsyndromic X-linked mental retardation. IL-1R9/IL1RAPL2 is highly homologous to IL-1R8. Both forms have no known ligands and receptor are found in the fetal brain. IL-1R9/IL1RAPL2 may function as a negative receptor. Both IL1RAPL1 and IL1RAPL2 have novel C-terminal sequences not present in other related proteins. IL-1R9/IL1RAPL2 may be strong candidates for X-linked non-syndromic mental retardation loci, and that molecules resembling IL-1 and IL-18 play a role in the development or function of the central nervous system.

Reference for IL-1 R9

  • Jin H, et al. (2000) Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation. Eur J Hum Genet. 8(2): 87-94.
  • Sana TR, et al. (2000) Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3. Genomics. 69(2): 252-62.
  • Gambino F, et al. (2007) IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. Proc Natl Acad Sci. 104(21): 9063-8.

IL-1 R9 Protein

IL-1 R9 protein expression

Tissue specificity

Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta.

IL-1 R9 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

IL-1 R9 Antibody

There are 2 IL-1 R9 antibodies which are validated in multiple tissues with various applications, including ELISA. There are 2 IL-1 R9 antibody for ELISA. Among all these IL-1 R9 antibodies, there are 1 anti-IL-1 R9 mouse monoclonal antibodies , 1 anti-IL-1 R9 rabbit polyclonal antibodies . All the IL-1 R9 anbodies are produced in house and all are in stock. IL-1 R9 antibody customerized service is available.

IL-1 R9 Gene

IL1RAPL2 gene / cDNA is a protein-coding gene which located on Xq22.3. The IL1RAPL2 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.189 organisms have orthologs with human gene IL1RAPL2.