IL-20: IL-20 Protein | IL-20 Antibody

IL-20 Gene family

IL-20 Background

IL2/Interleukin-2 belongs to the IL-1 family. It is a cytokine structurally related to interleukin 1. IL2/Interleukin-2 can be detected in skin, trachea, and other tissues. It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells.It has been shown that interleukin-2 transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. It may be involved in epidermal function and psoriasis. It also regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL2/Interleukin-2 also causes cell expansion of multipotential hematopoietic progenitor cells. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

Reference for IL-20

  • Chen XY, et al. (2011) The association between the IL-20-1723CG allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population. Dermatology. 222(1):24-30.
  • Baird AM, et al. (2011) IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. Eur J Cancer. 47(12):1908-18.
  • Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.

IL-20 Protein

IL-20 protein function

Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. {ECO:0000269|PubMed:16511554}.

IL-20 protein expression

Tissue specificity

Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.

Induction

Up-regulated by UV-B irradiation in epithelial keratinocytes.

IL-20 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    176.00
  • Mass (Da)
    20.00

IL-20 Antibody

There are 6 IL-20 antibodies which are validated in multiple tissues with various applications, including WB, IP, ELISA, ELISA(Det), ELISA(Cap). There are 1 IL-20 antibody for WB, 1 IL-20 antibody for IP, 4 IL-20 antibody for ELISA, 1 IL-20 antibody for ELISA(Det), 1 IL-20 antibody for ELISA(Cap). Among all these IL-20 antibodies, there are 3 anti-IL-20 rabbit polyclonal antibodies , 1 anti-IL-20 mouse monoclonal antibodies , 2 anti-IL-20 rabbit monoclonal antibodies . All the IL-20 anbodies are produced in house and all are in stock. IL-20 antibody customerized service is available.

IL-20 Gene

IL20 gene / cDNA is a protein-coding gene which located on 1q32.1. The IL20 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.117 organisms have orthologs with human gene IL20.