IL10RA cDNA Clone: Expression and Clone Vector / Plasmid
IL10RA cDNA / Gene Overview
IL10RA gene / cDNA is a protein-coding gene which located on 11q23.3. The IL10RA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.185 organisms have orthologs with human gene IL10RA.
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
IL10RA cDNA / Gene Sequence
LOCUS NM_001558 3672 bp mRNA linear PRI 17-JUN-2018
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