IL10RA cDNA Clone: Expression and Clone Vector / Plasmid

IL10RA cDNA / Gene Overview

IL10RA gene / cDNA is a protein-coding gene which located on 11q23.3. The IL10RA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.185 organisms have orthologs with human gene IL10RA.

IL10RA cDNA / Gene Function

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

IL10RA cDNA / Gene Sequence

LOCUS
LOCUS NM_001558 3672 bp mRNA linear PRI 17-JUN-2018
DEFINITION
Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant 1, mRNA.
ACCESSION
NM_001558
VERSION
NM_001558.3

This sequence information is just for reference only.

IL10RA Family & Reagents

IL10RA Gene family reagents (CD molecules)

Approved Symbol Reagent list
TLR3
FCGR2B
CD274
TNFRSF14
TNFSF13
KDR
LEPR
PTPRC
TNFRSF4
F3
Approved Symbol Reagent list
SLAMF8
TNFRSF8
FCGR3B
LAIR1
CD44
ENG
SLAMF6
IL10RB
TNFRSF11A
IL3Ra

IL10RA Gene family reagents (Interleukin receptors)

Approved Symbol Reagent list
IL6ST
IL18R1
IL20RA
IL31RA
IL17RD
IL1RAPL1
IL18RAP
IL1RL1
IL21R
IL17RB
Approved Symbol Reagent list
IL12RB1
IL22RA2
IL11RA
IL6R
IL1RAPL2
IL1R2
IL10RB
IL1R1
IL1RN
IL1RL2

IL10RA cDNA / Gene Alias

  • CD210
  • CD210a
  • CDW210A
  • HIL-10R

IL10RA cDNA / Gene Expression

Broad expression in spleen (RPKM 29.9), bone marrow (RPKM 20.8) and 18 other tissues