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IL11 Protein

IL11 Protein Overview

IL11 reagents

Biologic characterization by Paul et al. (1990) indicated that, in addition to stimulating plasmacytoma proliferation, IL11 stimulates T-cell-dependent development of immunoglobulin-producing B cells and collaborates with IL3 (147740) in supporting murine megakaryocyte colony formation. Du and Williams (1994) reviewed the pleiotropic effects of IL11 on hematopoietic cells. Du and Williams (1997) reviewed the molecular, cell biologic, and clinical aspects of interleukin-11. Cytokines in the IL11 subfamily participate in the regulation of bone cell proliferation and differentiation. Takeuchi et al. (2002) reported positive effects of IL11 on osteoblasts and bone formation. In transgenic mice, overexpression of the human IL11 gene resulted in the stimulation of bone formation to increase cortical thickness and strength of long bones.

IL11 protein family

Belongs to the IL-6 superfamily.

IL11 protein name

Recommended name
Interleukin-11
Short name
IL-11||AGIF
Aliases
adipogenesis inhibitory factor, AGIF, IL-11, oprelvekin
Alternative name
Adipogenesis inhibitory factor INN: Oprelvekin

IL11 Gene family protein

IL11 Protein Sequence

Species Human IL11 protein
Length 199
Mass (Da) 21429
Sequence Human IL11 protein sequence
Species Mouse IL11 protein
Length 199
Mass (Da) 21522
Sequence Mouse IL11 protein sequence
Species Rat IL11 protein
Length 199
Mass (Da) 21555
Sequence Rat IL11 protein sequence

IL11 Protein Molecular Weight & PI

Interleukin-11 precursor (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 22-199 Interleukin-11.

Molecular weight (Da)

19144.39

Theoretical pI

11.16

IL11 Protein Structure

The crystal structure of human interleukin-11
Deposited
2013-08-29   Released:  2014-09-03
Deposition Author(s)
Griffin, M.D.W.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.0900 Å
R-Value Free
0.242
R-Value Work
0.184
4MHL From PDB

Human IL11 protein Secondary structure

IL11 Protein Interaction

Recombinant IL11 Protein Feature

IL11 Protein, Mouse, Recombinant

High Purity
> 95 % as determined by SDS-PAGE.
Low Endotoxin
Please contact us for more information.
High Activity
Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 3-15 ng/ml.

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