Sino Biological - 공식 웹사이트

IL11 Protein

IL11 Protein Overview

IL11 reagents

Biologic characterization by Paul et al. (1990) indicated that, in addition to stimulating plasmacytoma proliferation, IL11 stimulates T-cell-dependent development of immunoglobulin-producing B cells and collaborates with IL3 (147740) in supporting murine megakaryocyte colony formation. Du and Williams (1994) reviewed the pleiotropic effects of IL11 on hematopoietic cells. Du and Williams (1997) reviewed the molecular, cell biologic, and clinical aspects of interleukin-11. Cytokines in the IL11 subfamily participate in the regulation of bone cell proliferation and differentiation. Takeuchi et al. (2002) reported positive effects of IL11 on osteoblasts and bone formation. In transgenic mice, overexpression of the human IL11 gene resulted in the stimulation of bone formation to increase cortical thickness and strength of long bones.

IL11 protein family

Belongs to the IL-6 superfamily.

IL11 protein name

Recommended name
Short name
adipogenesis inhibitory factor, AGIF, IL-11, oprelvekin
Alternative name
Adipogenesis inhibitory factor INN: Oprelvekin

IL11 Gene family protein

IL11 Protein Sequence

Species Human IL11 protein
Length 199
Mass (Da) 21429
Sequence Human IL11 protein sequence
Species Mouse IL11 protein
Length 199
Mass (Da) 21522
Sequence Mouse IL11 protein sequence
Species Rat IL11 protein
Length 199
Mass (Da) 21555
Sequence Rat IL11 protein sequence

IL11 Protein Molecular Weight & PI

Interleukin-11 precursor (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 22-199 Interleukin-11.

Molecular weight (Da)


Theoretical pI


IL11 Protein Structure

The crystal structure of human interleukin-11
2013-08-29   Released:  2014-09-03
Deposition Author(s)
Griffin, M.D.W.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
2.0900 Å
R-Value Free
R-Value Work

Human IL11 protein Secondary structure

IL11 Protein Interaction

Recombinant IL11 Protein Feature

IL11 Protein, Mouse, Recombinant

High Purity
> 95 % as determined by SDS-PAGE.
Low Endotoxin
Please contact us for more information.
High Activity
Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 3-15 ng/ml.

Bulk Order of Recombinant IL11 Protein

Please Leave Us a Message if you have any questions regarding bulk price quote of our products on the website, our customer specialist will get back to you in 24 hours by email.

Custom Recombinant Protein Production Service Features

  • Over 10 years' experience for 6000+ recombinant proteins production.
  • One-stop service from gene synthesis and vector construction to protein expression and purification.
  • Multiple protein expression systems: bacterial, yeast, baculovirus-insect and mammalian expression system.
  • Multiple purification systems (30+) to choose.
  • High R & D ability with over 1000 new proteins per year and quick problem-solving ability.
  • Close to 100 bioreactors with various volume between 2-1000 L to guarantee high-throughput and large-scale production.

Custom Recombinant Protein Production Service Advantages

  • High-efficiency expression vectors
  • High cell density culturing
  • Proprietary medium formulation
  • >6000 proteins expression and purification experience
  • High-efficiency expression vectors
  • High cell density culturing

Recombinant Protein Production Service Description

We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.