Ki67/MKI67 Information: Ki67/MKI67 Protein, Ki67/MKI67 Antibody and Ki67/MKI67 Gene

Ki67/MKI67 Gene family

Ki67/MKI67 Protein

Ki67/MKI67 protein function

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226}.

Ki67/MKI67 protein expression

Induction

Expression occurs preferentially during late G1, S, G2 and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected (at protein level) (PubMed:6206131). Present at highest level in G2 phase and during mitosis (at protein level). In interphase, forms fiber-like structures in fibrillarin-deficient regions surrounding nucleoli (PubMed:2674163, PubMed:8799815).

Ki67/MKI67 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    3,256.00
  • Mass (KDa)
    358.00

Ki67/MKI67 Antibody

There are 9 Ki67/MKI67 antibodies which are validated in multiple tissues with various applications, including ICC/IF, IHC-P, WB, ELISA. There are 2 Ki67/MKI67 antibody for ICC/IF, 4 Ki67/MKI67 antibody for IHC-P, 3 Ki67/MKI67 antibody for WB, 2 Ki67/MKI67 antibody for ELISA. Among all these Ki67/MKI67 antibodies, there are 5 anti-Ki67/MKI67 mouse monoclonal antibodies , 4 anti-Ki67/MKI67 rabbit polyclonal antibodies . All the Ki67/MKI67 anbodies are produced in house and all are in stock. Ki67/MKI67 antibody customerized service is available.

Ki67/MKI67 Gene

MKI67 gene / cDNA is a protein-coding gene which located on 10q26.2. The MKI67 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.193 organisms have orthologs with human gene MKI67.