High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
MS4A2 cDNA / gene is a gene with protein product which located on 11q12.1. The MS4A2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 105 organisms have orthologs with human gene MS4A2.
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