Myelin Oligodendrocyte Glycoprotein Protein Overview: Sequence, Structure, Function and Protein Interaction

Myelin Oligodendrocyte Glycoprotein Protein Overview

Pham-Dinh et al. (1993) isolated bovine, mouse, and rat MOG cDNAs. The predicted sequences of the mature MOG proteins are highly conserved. All contain 2 transmembrane segments and have an N-terminal, extracellular region with characteristics of an immunoglobulin variable domain. The N terminus shows strong homology with the N terminus of butyrophilin (601610), a protein expressed in the lactating mammary gland. Hilton et al. (1995) cloned a human MOG cDNA encoding a predicted polypeptide containing a signal peptide of 29 amino acids followed by 218 amino acids of mature protein. Like its bovine and murine counterparts, it contains an Ig-like domain and 2 putative transmembrane domains. It has a potential N-linked glycosylation site at asn31. Despite the similar names, oligodendrocyte-myelin glycoprotein (OMG; 164345) is a separate protein encoded within a large intron of the NF1 gene (613113). The 2 glycoproteins are associated specifically with oligodendrocytes and myelin, but have quite different roles in myelinogenesis and are structurally unrelated (Pham-Dinh, 1994). MOG is an intrinsic membrane molecule with 2 transmembrane domains, whereas OMG is anchored in the outer leaflet of the plasma membrane through a glycophospholipid tail. OMG belongs to the family of proteins with a series of tandem leucine-rich repeats, while MOG is a member of the Ig superfamily.

Myelin Oligodendrocyte Glycoprotein protein family

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Myelin Oligodendrocyte Glycoprotein protein name

Recommended name
Myelin-oligodendrocyte glycoprotein
Aliases
BTN6, BTNL11

Myelin Oligodendrocyte Glycoprotein Protein Sequence

Species Human Myelin Oligodendrocyte Glycoprotein protein
Length 247
Mass (Da) 28193
Sequence Human Myelin Oligodendrocyte Glycoprotein protein sequence
Species Mouse Myelin Oligodendrocyte Glycoprotein protein
Length 246
Mass (Da) 28271
Sequence Mouse Myelin Oligodendrocyte Glycoprotein protein sequence
Species Rat Myelin Oligodendrocyte Glycoprotein protein
Length 245
Mass (Da) 27882
Sequence Rat Myelin Oligodendrocyte Glycoprotein protein sequence

Myelin Oligodendrocyte Glycoprotein Protein Molecular Weight & PI

Myelin-oligodendrocyte glycoprotein precursor Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 30-247 Myelin-oligodendrocyte glycoprotein.

Molecular weight (Da)

25110.33

Theoretical pI

8.86

Myelin Oligodendrocyte Glycoprotein Protein Structure

HOMOLOGY MODEL OF THE EXTRACELLULAR DOMAIN OF HUMAN MYELIN TITLE 2 OLIGODENDROCYTE GLYCOPROTEIN
Deposition Author(s)
N.BELMAR,M.COSMAN,C.GENAIN,V.KRISHNAN,C.LU,R.MAXWELL,M.MESLEH
Experimental Data Snapshot
1Q70 From PDB

Myelin Oligodendrocyte Glycoprotein Protein Interaction

Recombinant Myelin Oligodendrocyte Glycoprotein Protein Feature

Myelin Oligodendrocyte Glycoprotein Protein, Mouse, Recombinant (aa30-149, His Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.

Recombinant Myelin Oligodendrocyte Glycoprotein protein citations

Title
Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis
Year
2013
Author
A Billich, T Baumruker, C Beerli, M Bigaud, C Bruns…
Journal
PloS one
Title
Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages
Year
2017
Author
Jiang, W;Li, D;Han, R;Zhang, C;Jin, WN;Wood, K;Liu, Q;Shi, FD;Hao, J;
Journal
Proc. Natl. Acad. Sci. U.S.A.

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