NNT1 cDNA Clone: Expression and Clone Vector / Plasmid
NNT1 cDNA / Gene Overview
CLCF1 gene / cDNA is a protein-coding gene which located on 11q13.2. The CLCF1 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.196 organisms have orthologs with human gene CLCF1.
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
NNT1 cDNA / Gene Sequence
LOCUS NM_013246 1860 bp mRNA linear PRI 23-JUN-2018
Homo sapiens cardiotrophin like cytokine factor 1 (CLCF1), transcript variant 1, mRNA.
This sequence information is just for reference only.
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