Osteoprotegerin: Osteoprotegerin Protein | Osteoprotegerin Antibody

Osteoprotegerin Gene family

Osteoprotegerin Background

Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

Reference for Osteoprotegerin

  • Collin-Osdoby P. (2005) Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 95 (11): 1046-57.
  • Boyce BF, et al. (2007) Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 9 Suppl 1: S1.
  • Blázquez-Medela AM, et al. ( 2011) Osteoprotegerin and diabetes-associated pathologies. Curr Mol Med. 11 (5): 401-16.

Osteoprotegerin Protein

Osteoprotegerin protein function

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.

Osteoprotegerin protein expression

Tissue specificity

Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

Induction

Up-regulated by increasing calcium-concentration in the medium and estrogens. Down-regulated by glucocorticoids.

Osteoprotegerin protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    401.00
  • Mass (Da)
    46.00

Osteoprotegerin Antibody

There are 4 Osteoprotegerin antibodies which are validated in multiple tissues with various applications, including ELISA, ICC/IF. There are 3 Osteoprotegerin antibody for ELISA, 1 Osteoprotegerin antibody for ICC/IF. Among all these Osteoprotegerin antibodies, there are 1 anti-Osteoprotegerin rabbit monoclonal antibodies , 3 anti-Osteoprotegerin rabbit polyclonal antibodies . All the Osteoprotegerin anbodies are produced in house and all are in stock. Osteoprotegerin antibody customerized service is available.

Osteoprotegerin Gene

TNFRSF11B gene / cDNA is a protein-coding gene which located on 8q24.12. The TNFRSF11B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.218 organisms have orthologs with human gene TNFRSF11B.