p38 Protein Overview: Sequence, Structure, Function and Protein Interaction

p38 Protein Overview

CSAID-BINDING PROTEIN 2, INCLUDED

p38 protein family

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

p38 protein name

Recommended name
Mitogen-activated protein kinase 14
Short name
MAP kinase 14||MAPK 14||CSAID-binding protein
Aliases
Mxi2, p38, p38 MAP kinase, PRKM14, PRKM15
Alternative name
Cytokine suppressive anti-inflammatory drug-binding protein MAP kinase MXI2 MAX-interacting protein 2 Mitogen-activated protein kinase p38 alpha Stress-activated protein kinase 2a

p38 Gene family protein

p38 Protein Sequence

Species Human p38 protein
Length 360
Mass (Da) 41293
Sequence Human p38 protein sequence
Species Mouse p38 protein
Length 360
Mass (Da) 41287
Sequence Mouse p38 protein sequence
Species Rat p38 protein
Length 360
Mass (Da) 41321
Sequence Rat p38 protein sequence

p38 Protein Molecular Weight & PI

Mitogen-activated protein kinase 14 (EC 2.7.11.24) (MAP kinase 14) (MAPK 14) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 2-360 Mitogen-activated protein kinase 14.

Molecular weight (Da)

41162.1

Theoretical pI

5.48

p38 Protein Structure

Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE
Deposited
2013-05-02   Released:  2013-06-12
Deposition Author(s)
Sack, J.S., Tokarski, J.S.
Organism(s)
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
1.9700 Å
R-Value Free
0.217
R-Value Work
0.184
4KIN From PDB

Human p38 protein Secondary structure

p38 Protein Interaction

Recombinant p38 Protein Feature

p38 Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Kinase activity untested

Recombinant p38 protein citations

Title
Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum
Year
2015
Author
Bhalla, K;Chugh, M;Mehrotra, S;Rathore, S;Tousif, S;Prakash Dwivedi, V;Prakash, P;Kumar Samuchiwal, S;Kumar, S;Kumar Singh, D;Ghanwat, S;Kumar, D;Das, G;Mohmmed, A;Malhotra, P;Ranganathan, A;
Journal
Nat Commun
Title
Surface plasmon resonance imaging validation of small molecule drugs binding on target protein microarrays
Year
2018
Author
Zhou, W;Yang, M;Li, S;Zhu, J;
Journal
Applied Surface Science

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