RANKL Information: RANKL Protein, RANKL Antibody and RANKL Gene

RANKL Gene family

RANKL Protein

RANKL protein function

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity). {ECO:0000250|UniProtKB:O35235, ECO:0000269|PubMed:22664871}.

RANKL protein expression

Tissue specificity

Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.

Induction

Up-regulated by T-cell receptor stimulation.

RANKL protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    317.00
  • Mass (Da)
    35.00

RANKL Antibody

There are 8 RANKL antibodies which are validated in multiple tissues with various applications, including ELISA, Neutralization, WB, ELISA(Det), IP, ELISA(Cap). There are 5 RANKL antibody for ELISA, 1 RANKL antibody for Neutralization, 3 RANKL antibody for WB, 1 RANKL antibody for ELISA(Det), 1 RANKL antibody for IP, 1 RANKL antibody for ELISA(Cap). Among all these RANKL antibodies, there are 1 anti-RANKL mouse monoclonal antibodies , 4 anti-RANKL rabbit monoclonal antibodies , 3 anti-RANKL rabbit polyclonal antibodies . All the RANKL anbodies are produced in house and all are in stock. RANKL antibody customerized service is available.

RANKL Gene

TNFSF11 gene / cDNA is a protein-coding gene which located on 13q14. The TNFSF11 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.220 organisms have orthologs with human gene TNFSF11.