TROY: TROY Protein | TROY Antibody

TROY Gene family

TROY Background

Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the ductal epithelium of the prostate and parotid glands. TNFRSF19/TROY expression is detected in some adenocarcinoma cell lines that arise from this tissue. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. TNFRSF19/TROY is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. TNFRSF19/TROY was negatively regulated by adipogenic transcription factor CCAAT/enhancer-binding proteins (C/EBP). TNFRSF19 signals activation of the Jnk pathway and induces cell death. Overexpression of TNFRSF19 also signals NFB activation, comparable and similar to that by p75NGFR. TNFRSF19/TROY is capable of activating key signaling pathways of the TNF receptor family, and its predominant expression patterns suggest that it plays a role in the growth and regulation of epithelial tissues.

Reference for TROY

  • Hu S, et al. (1999) Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Genomics. 62(1): 103-7.
  • Qiu W, et al. (2010) Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP. J Biol Chem. 285(19): 14438-49.
  • Hisaoka T, et al. (2006) Characterization of TROY/TNFRSF19/TAJ-expressing cells in the adult mouse forebrain. Brain Res. 1110(1): 81-94.

TROY Protein

TROY protein function

Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

TROY protein expression

Tissue specificity

Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.

TROY protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    423.00
  • Mass (Da)
    46.00

TROY Antibody

There are 7 TROY antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA, ELISA(Cap). There are 2 TROY antibody for IHC-P, 5 TROY antibody for ELISA, 1 TROY antibody for ELISA(Cap). Among all these TROY antibodies, there are 3 anti-TROY rabbit polyclonal antibodies , 2 anti-TROY mouse monoclonal antibodies , 2 anti-TROY rabbit monoclonal antibodies . All the TROY anbodies are produced in house and all are in stock. TROY antibody customerized service is available.

TROY Gene

TNFRSF19 gene / cDNA is a protein-coding gene which located on 13q12.12. The TNFRSF19 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog.213 organisms have orthologs with human gene TNFRSF19.