Anti-VNN2 Antibody (PE)

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Anti-VNN2 Antibody (PE) (Mouse Monoclonal antibody) General Information

Product name
Anti-VNN2 Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human VNN2
Immunogen
Recombinant Human VNN2 / Vanin-2 protein (Catalog#11728-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human VNN2 / Vanin-2 (rh VNN2 / Vanin-2; Catalog#11728-H08H; NP_004656.2; Met 1-Ser 492) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Mouse IgG1 Clone #04
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
5 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-VNN2 Antibody (PE) (Mouse Monoclonal antibody) Images

Flow cytometric analysis of anti-human VNN2 on human whole blood monocytes (left panel) and granulocytes (right panel). The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable monocytes and granulocytes.

Anti-VNN2 Antibody (PE): Alternative Names

Anti-FOAP-4 Antibody; Anti-GPI-80 Antibody; Anti-VNN2 Antibody

VNN2 Background Information

Vascular non-inflammatory molecule 2, also known as glycosyl-phosphatidyl inositol-anchored protein GPI-8, Vanin-2, Protein FOAP-4 and VNN2, is a cell membrane protein which belongs to theCN hydrolase family and Vanin subfamily. VNN2 is widely expressed with higher expression in spleen and blood. VNN2 is a member of the vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. VNN2 is an amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. It is involved in the thymus homing of bone marrow cells. VNN2 plays a role in transendothelial migration of neutrophils and may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
Full Name
vanin 2
References
  • Suzuki K. et al., 1999, J. Immunol. 162: 4277-84.
  • Martin, F. et al., 2001,Immunogenetics. 53 (4):296-306.
  • Liu T.et al., 2005, J. Proteome Res. 4: 2070-80.
  • Jansen P.AM. et al., 2009, J. Invest. Dermatol. 129: 2167-74.
  • Trametinib Drives T-cell-Dependent Control of KRAS-Mutated Tumors by Inhibiting Pathological Myelopoiesis
    Author
    Allegrezza, MJ;Rutkowski, MR;Stephen, TL;Svoronos, N;Perales-Puchalt, A;Nguyen, JM;Payne, KK;Singhal, S;Eruslanov, EB;Tchou, J;Conejo-Garcia, JR;
    Year
    2016
    Journal
    Cancer Res.
    Application
    FAC

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